2f9g Summary


Crystal structure of Fus3 phosphorylated on Tyr182

The structure was published by Bhattacharyya, R.P., Remenyi, A., Good, M.C., Bashor, C.J., Falick, A.M., and Lim, W.A., in 2006 in a paper entitled "The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase FUS3. This molecule has the UniProt identifier P16892 (FUS3_YEAST)search. The sample contained 353 residues which is 100% of the natural sequence. Out of 353 residues 328 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase FUS3 P16892 (1-353) (FUS3_YEAST)search Saccharomyces cerevisiae S288csearch 100% 353 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P16892 (1 - 353) Mitogen-activated protein kinase FUS3 Saccharomyces cerevisiae

Chain Structural classification (CATH) Sequence family (Pfam)
A (P16892) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P16892) protein kinase activitysearch ATP bindingsearch identical protein bindingsearch protein bindingsearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch kinase activitysearch nucleotide bindingsearch transferase activitysearch protein phosphorylationsearch MAPK cascadesearch cell divisionsearch cell cyclesearch conjugationsearch positive regulation of protein export from nucleussearch cell cycle arrestsearch pheromone-dependent signal transduction involved in conjugation with cellular fusionsearch invasive growth in response to glucose limitationsearch mitotic nuclear divisionsearch phosphorylationsearch negative regulation of MAPK cascadesearch negative regulation of transposition, RNA-mediatedsearch cytoplasmsearch nucleussearch periplasmic spacesearch mating projection tipsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch