2f8y Summary


Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution.

The structure was published by Nam, Y., Sliz, P., Song, L., Aster, J.C., and Blacklow, S.C., in 2006 in a paper entitled "Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.55 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Notch homolog 1, translocation-associated (Drosophila).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Notch homolog 1, translocation-associated (Drosophila) P46531 (1905-2126) (NOTC1_HUMAN)search Homo sapienssearch < 90% 223 96%
B Notch homolog 1, translocation-associated (Drosophila) P46531 (1905-2126) (NOTC1_HUMAN)search Homo sapienssearch < 90% 223 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P46531 (1905 - 2126) Notch homolog 1, translocation-associated (Drosophila) Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch Ankyrin repeatsearch, Ankyrin repeats (3 copies)search, Ankyrin repeats (many copies)search
Chain InterPro annotation
A, B Ankyrin repeatsearch Ankyrin repeat-containing domainsearch