2f8y Summary

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Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution.

The structure was published by Nam, Y., Sliz, P., Song, L., Aster, J.C., and Blacklow, S.C., in 2006 in a paper entitled "Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.55 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Notch homolog 1, translocation-associated (Drosophila).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Notch homolog 1, translocation-associated (Drosophila) P46531 (1905-2126) (NOTC1_HUMAN)search Homo sapienssearch < 90% 223 96%
B Notch homolog 1, translocation-associated (Drosophila) P46531 (1905-2126) (NOTC1_HUMAN)search Homo sapienssearch < 90% 223 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P46531 (1905 - 2126) Notch homolog 1, translocation-associated (Drosophila) Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch Ankyrin repeatsearch, Ankyrin repeats (3 copies)search, Ankyrin repeats (many copies)search
Chain InterPro annotation
A, B Ankyrin repeatsearch Ankyrin repeat-containing domainsearch