2f7z Summary


Protein Kinase A bound to (R)-1-(1H-Indol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphtyridin-5-yloxy)-ehylamine

The structure was published by Li, Q., Woods, K.W., Thomas, S., et al., Jakob, C.G., Rosenberg, S.H., and Giranda, V.L., in 2006 in a paper entitled "Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely cAMP-dependent protein kinase, alpha-catalytic subunit and PKI, inhibitory peptide.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
E cAMP-dependent protein kinase, alpha-catalytic subunit P00517 (1-351) (KAPCA_BOVIN)search Bos taurussearch 96% 351 95%
I PKI, inhibitory peptide P61926 (6-25) (IPKA_RABIT)search Oryctolagus cuniculussearch < 90% 20 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00517 (1 - 351) cAMP-dependent protein kinase, alpha-catalytic subunit Bos taurus
P61926 (6 - 25) PKI, inhibitory peptide

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
E (P00517) Protein kinases, catalytic subunitsearch Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch
I cAMP-dependent protein kinase inhibitorsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
E (P00517) plasma membranesearch neuromuscular junctionsearch mitochondrionsearch cytoplasmsearch membranesearch extracellular vesicular exosomesearch nucleussearch centrosomesearch sperm midpiecesearch AMP-activated protein kinase complexsearch ciliary basesearch regulation of protein processingsearch peptidyl-serine phosphorylationsearch negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningsearch protein autophosphorylationsearch positive regulation of protein export from nucleussearch sperm capacitationsearch neural tube closuresearch protein phosphorylationsearch regulation of tight junction assemblysearch cellular response to glucose stimulussearch positive regulation of cell cycle arrestsearch peptidyl-threonine phosphorylationsearch cellular response to parathyroid hormone stimulussearch regulation of proteasomal protein catabolic processsearch phosphorylationsearch regulation of osteoblast differentiationsearch mesoderm formationsearch regulation of synaptic transmissionsearch protein kinase activitysearch protein serine/threonine kinase activitysearch nucleotide bindingsearch protein kinase bindingsearch protein bindingsearch kinase activitysearch protein serine/threonine/tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch cAMP-dependent protein kinase activitysearch protein kinase A regulatory subunit bindingsearch ubiquitin protein ligase bindingsearch transferase activitysearch

Chain InterPro annotation
E Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
I cAMP-dependent protein kinase inhibitorsearch