2f6w Summary

pdbe.org/2f6w
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Protein tyrosine phosphatase 1B with sulfamic acid inhibitors

The structure was published by Klopfenstein, S.R., Evdokimov, A.G., Colson, A.-O., et al., Downs, T.R., Kasibhatla, B., and Peters, K.G., in 2006 in a paper entitled "1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Tyrosine-protein phosphatase, non-receptor type 1. This molecule has the UniProt identifier P18031 (PTN1_HUMAN)search. The sample contained 298 residues which is < 90% of the natural sequence. Out of 298 residues 297 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein phosphatase, non-receptor type 1 P18031 (1-298) (PTN1_HUMAN)search Homo sapienssearch < 90% 298 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P18031 (1 - 298) Tyrosine-protein phosphatase, non-receptor type 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Higher-molecular-weight phosphotyrosine protein phosphatasessearch Protein tyrosine phosphatase superfamilysearch Protein-tyrosine phosphatasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (P18031) dephosphorylationsearch protein dephosphorylationsearch protein tyrosine phosphatase activitysearch phosphatase activitysearch

Chain InterPro annotation
A Protein-tyrosine phosphatase, receptor/non-receptor typesearch Protein-tyrosine/Dual specificity phosphatasesearch Protein-tyrosine phosphatase, active sitesearch Protein-tyrosine phosphatase-likesearch