Protein tyrosine phosphatase 1B with sulfamic acid inhibitors
The structure was published by Klopfenstein, S.R., Evdokimov, A.G., Colson, A.-O., et al., Downs, T.R., Kasibhatla, B., and Peters, K.G., in 2006 in a paper entitled "1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2005.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Tyrosine-protein phosphatase, non-receptor type 1. This molecule has the UniProt identifier P18031 (PTN1_HUMAN). The sample contained 298 residues which is < 90% of the natural sequence. Out of 298 residues 297 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: