2f57 Summary


Crystal Structure Of The Human P21-Activated Kinase 5

The structure was published by Eswaran, J., Lee, W.H., Debreczeni, J.E., et al., Deacon, S.W., Peterson, J.R., and Knapp, S., in 2007 in a paper entitled "Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Serine/threonine-protein kinase PAK 7.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase PAK 7 Q9P286 (425-719) (PAK7_HUMAN)search Homo sapienssearch < 90% 317 94%
B Serine/threonine-protein kinase PAK 7 Q9P286 (425-719) (PAK7_HUMAN)search Homo sapienssearch < 90% 317 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9P286 (425 - 719) Serine/threonine-protein kinase PAK 7 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (Q9P286) protein phosphorylationsearch cell growthsearch apoptotic processsearch cytoskeleton organizationsearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Serine/threonine-protein kinase PAK7search