Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680
The structure was published by Young, M.A., Shah, N.P., Chao, L.H., et al., Lockhart, D.J., Sawyers, C.L., and Kuriyan, J., in 2006 in a paper entitled "Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.91 Å and deposited in 2005.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Proto-oncogene tyrosine-protein kinase ABL1.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: