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PDBe Entry: 2f2l view

Crystal structure of tracheal cytotoxin (TCT) bound to the ectodomain complex of peptidoglycan recognition proteins LCa (PGRP-LCa) and LCx (PGRP-LCx)
Summary
Header MEMBRANE PROTEIN, IMMUNE SYSTEM, TOXINsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.1 Å, R-factor: 16.872%, Free R-factor: 21.378%, Spacegroup: P 21 21 21
Released 04/04/2006, deposition: 17/11/2005, last revision: 24/02/2009
Authors Chang, C.I.search; Deisenhofer, J.search
Primary citation Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor.
SCIENCEsearch vol:311, pag:1761-1764 (2006) [PubMed ID 16556841 ]search
Keywords Protein-peptidoglycan complexsearch, MEMBRANE PROTEINsearch, IMMUNE SYSTEMsearch, TOXINsearch
Organism Drosophila melanogaster(fruit fly) 7227search(A X)
UniProt Peptidoglycan-recognition protein-LC (Immune response deficient 7 protein) Q9GNK5search (A X)
Solvent A, X
Polymers
Id Name Type UniProt Residues Observed
A Peptidoglycan-recognition protein-LC isoform LCa Protein Q9GNK5 (PGPLC_DROME)search
167 100%
X Peptidoglycan recognition protein-LC isoform LCx Protein Q9GNK5 (PGPLC_DROME)search
167 99%
Heterogens
Id Name Ligands
A SUGAR (N-ACETYL-D-GLUCOSAMINE) NAG search
A SUGAR (2-(ACETYLAMINO)-2-DEOXY-ALPHA-L-IDOPYRANOSE) HSQ search
A, X SULFATE ION SO4 search
X GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA MLD search
X CITRIC ACID CIT search
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