2f2c Summary


X-ray structure of human CDK6-Vcyclinwith the inhibitor aminopurvalanol

The structure was published by Lu, H. and Schulze-Gahmen, U., in 2006 in a paper entitled "Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Cyclin homolog and Cell division protein kinase 6.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cyclin homolog Q01043 (1-254) (CGH2_SHV21)search Herpesvirus saimiri (strain 11)search 90% 254 96%
B Cell division protein kinase 6 Q00534 (1-308) (CDK6_HUMAN)search Homo sapienssearch 92% 308 90%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q01043 (1 - 254) Cyclin homolog Herpesvirus saimiri (strain 11)
Q00534 (1 - 308) Cell division protein kinase 6 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q01043) Cyclinsearch Cyclin A; domain 1search PF00134: Cyclin, N-terminal domainsearch, PF09241: Herpesviridae viral cyclinsearch
B (Q00534) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q01043) modulation by virus of host cell cyclesearch cell cyclesearch viral processsearch cell divisionsearch
B (Q00534) cell cyclesearch lateral ventricle developmentsearch regulation of cell motilitysearch type B pancreatic cell developmentsearch G1/S transition of mitotic cell cyclesearch response to virussearch positive regulation of cell-matrix adhesionsearch cell divisionsearch positive regulation of fibroblast proliferationsearch dentate gyrus developmentsearch regulation of cell proliferationsearch protein phosphorylationsearch cell dedifferentiationsearch astrocyte developmentsearch cell cycle arrestsearch phosphorylationsearch gliogenesissearch cell differentiationsearch Notch signaling pathwaysearch negative regulation of epithelial cell proliferationsearch hematopoietic stem cell differentiationsearch T cell differentiation in thymussearch generation of neuronssearch positive regulation of gene expressionsearch negative regulation of cell proliferationsearch negative regulation of cell cyclesearch negative regulation of cellular senescencesearch hemopoiesissearch hematopoietic progenitor cell differentiationsearch negative regulation of cell differentiationsearch negative regulation of myeloid cell differentiationsearch regulation of erythrocyte differentiationsearch regulation of gene expressionsearch negative regulation of osteoblast differentiationsearch mitotic cell cyclesearch transferase activitysearch protein bindingsearch cyclin bindingsearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch nucleotide bindingsearch nucleussearch rufflesearch cyclin-dependent protein kinase holoenzyme complexsearch cytoplasmsearch cytosolsearch cell projectionsearch nucleolussearch

Chain InterPro annotation
A Cyclin, N-terminalsearch Cyclin-likesearch Cyclin domain, herpesvirussearch Cyclin, herpesvirussearch
B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Cyclin-dependent kinase 6search