2f29 Summary


Crystal Structure of the Human Sialidase Neu2 Q116E Mutant in Complex with DANA Inhibitor

A publication describing this structure is not available. The depositing authors are Chavas, L.M.G.search; Kato, R.search; Fusi, P.search; Tringali, C.search; Venerando, B.search; Tettamanti, G.search; Monti, E.search; Wakatsuki, S.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.921 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Sialidase 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Sialidase 2 Q9Y3R4 (1-380) (NEUR2_HUMAN)search Homo sapienssearch 100% 382 96%
B Sialidase 2 Q9Y3R4 (1-380) (NEUR2_HUMAN)search Homo sapienssearch 100% 382 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9Y3R4 (1 - 380) Sialidase 2 Homo sapiens

Chain Sequence family (Pfam)
A, B (Q9Y3R4) PF13088: BNR repeat-like domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (Q9Y3R4) exo-alpha-sialidase activitysearch hydrolase activitysearch exo-alpha-(2->3)-sialidase activitysearch hydrolase activity, acting on glycosyl bondssearch exo-alpha-(2->6)-sialidase activitysearch exo-alpha-(2->8)-sialidase activitysearch cytoplasmsearch cytosolsearch metabolic processsearch lipid catabolic processsearch glycosphingolipid metabolic processsearch sphingolipid metabolic processsearch small molecule metabolic processsearch ganglioside catabolic processsearch lipid metabolic processsearch carbohydrate metabolic processsearch oligosaccharide catabolic processsearch

Chain InterPro annotation
A, B Sialidasessearch Sialidase familysearch Sialidase-2search