2f0z Summary


Crystal Structure of the Human Sialidase Neu2 in Complex with Zanamivir inhibitor

A publication describing this structure is not available. The depositing authors are Chavas, L.M.G.search; Kato, R.search; McKimm-Breschkin, J.search; Colman, P.M.search; Fusi, P.search; Tringali, C.search; Venerando, B.search; Tettamanti, G.search; Monti, E.search; Wakatsuki, S.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Sialidase 2. This molecule has the UniProt identifier Q9Y3R4 (NEUR2_HUMAN)search. The sample contained 382 residues which is 100% of the natural sequence. Out of 382 residues 356 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Sialidase 2 Q9Y3R4 (1-380) (NEUR2_HUMAN)search Homo sapienssearch 100% 382 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9Y3R4 (1 - 380) Sialidase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q9Y3R4) Sialidases (neuraminidases)search Neuraminidasesearch PF13088: BNR repeat-like domainsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (Q9Y3R4) cytoplasmsearch cytosolsearch exo-alpha-(2->3)-sialidase activitysearch hydrolase activitysearch hydrolase activity, acting on glycosyl bondssearch exo-alpha-(2->6)-sialidase activitysearch exo-alpha-(2->8)-sialidase activitysearch exo-alpha-sialidase activitysearch carbohydrate metabolic processsearch ganglioside catabolic processsearch lipid catabolic processsearch sphingolipid metabolic processsearch oligosaccharide catabolic processsearch lipid metabolic processsearch small molecule metabolic processsearch metabolic processsearch glycosphingolipid metabolic processsearch

Chain InterPro annotation
A Sialidasessearch Sialidase familysearch Sialidase-2search