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PDBe Entry: 2f0y 
Crystal Structure Of Human Protein Farnesyltransferase Complexed With Farnesyl Diphosphate and hydantoin derivative
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TRANSFERASE
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X-RAY DIFFRACTION
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Resolution: 2.7 Å, R-factor: 21.2%, Free R-factor: 25.8%, Spacegroup: P 61
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14/11/2006, deposition: 14/11/2005, last revision: 24/02/2009
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Kim, K.H.; Lee, J.; Kim, J.
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hydantoin derivatives as Non-pepridic inhibitors of Ras Farnesyl transferase
To be published
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farnesyltransferase
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2.5.1.58 ExPASy BRENDA (A B), 2.5.1.59 ExPASy BRENDA (A)
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Homo sapiens(human) 9606(A B)
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Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (Ras proteins prenyltransferase alpha) (FTase-alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) P49354 (A)
Protein farnesyltransferase subunit beta (EC 2.5.1.58) (FTase-beta) (CAAX farnesyltransferase subunit beta) (RAS proteins prenyltransferase beta) P49356 (B)
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A, B
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| A |
Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit |
Protein |
P49354 (FNTA_HUMAN)
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379 |
82% |
| B |
Protein farnesyltransferase beta subunit |
Protein |
P49356 (FNTB_HUMAN)
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437 |
90% |
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| B |
ZINC ION |
ZN
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| B |
FARNESYL DIPHOSPHATE |
FPP
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| B |
3-({3-[3-(1H-IMIDAZOL-1-YL)PROPYL]-5-METHYL-5-(1-NAPHTHYL)-2,4-DIOXOIMIDAZOLIDIN-1-YL}METHYL)BENZONITRILE |
3MN
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