2exm Summary


Human CDK2 in complex with isopentenyladenine

The structure was published by Schulze-Gahmen, U., Brandsen, J., Jones, H.D., et al., Meijer, L., Vesely, J., and Kim, S.H., in 1995 in a paper entitled "Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 298 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P24941) protein phosphorylationsearch Ras protein signal transductionsearch positive regulation of transcription, DNA-templatedsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch positive regulation of cell proliferationsearch centrosome duplicationsearch phosphorylationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch G2/M transition of mitotic cell cyclesearch DNA replicationsearch mitotic cell cyclesearch regulation of gene silencingsearch potassium ion transportsearch cellular response to DNA damage stimulussearch cell cyclesearch meiotic nuclear divisionsearch G1/S transition of mitotic cell cyclesearch blood coagulationsearch mitotic G2 phasesearch positive regulation of DNA-dependent DNA replication initiationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch histone phosphorylationsearch cell divisionsearch mitotic G1 DNA damage checkpointsearch cellular response to nitric oxidesearch mitotic nuclear divisionsearch DNA repairsearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein bindingsearch cyclin bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch metal ion bindingsearch transferase activitysearch nucleotide bindingsearch histone kinase activitysearch kinase activitysearch nucleoplasmsearch endosomesearch cytosolsearch nucleussearch Y chromosomesearch centrosomesearch chromosome, telomeric regionsearch X chromosomesearch condensed chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch Cajal bodysearch microtubule organizing centersearch cytoplasmsearch cytoskeletonsearch transcription factor complexsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch