2exf Summary


Solution structure of the HIV-1 nucleocapsid (NCp7(12-55)) complexed with the DNA (-) Primer Binding Site

The structure was published by Bourbigot, S., Ramalanjaona, N., Boudier, C., et al., Mely, Y., Bouaziz, S., and Morellet, N., in 2008 in a paper entitled "How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely 5'-D(*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*C)-3' and Nucleocapsid protein* (NC*).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Nucleocapsid protein* (NC*) P03366 (390-432) (POL_HV1B1)search Human immunodeficiency virus type 1 BH10search < 90% 44 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03366 (390 - 432) Nucleocapsid protein* (NC*)

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Retrovirus zinc finger-like domainssearch HIV-1 Nucleocapsid Proteinsearch Zinc knucklesearch
Chain InterPro annotation
A Zinc finger, CCHC-typesearch