2exc Summary

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Inhibitor complex of JNK3

A publication describing this structure is not available. The depositing authors are Xue, Y.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.75 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 10. This molecule has the UniProt identifier P53779 (MK10_HUMAN)search. The sample contained 356 residues which is < 90% of the natural sequence. Out of 356 residues 334 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
X Mitogen-activated protein kinase 10 P53779 (45-400) (MK10_HUMAN)search Homo sapienssearch 91% 356 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P53779 (45 - 400) Mitogen-activated protein kinase 10 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
X (P53779) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
X (P53779) protein kinase activitysearch protein serine/threonine kinase activitysearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
X Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, JNKsearch Protein kinase-like domainsearch