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Structural Basis for the Interaction of TAK1 Kinase with its Activating Protein TAB1

The structure was published by Brown, K., Vial, S.C., Dedi, N., Long, J.M., Dunster, N.J., and Cheetham, G.M., in 2005 in a paper entitled "Structural basis for the interaction of TAK1 kinase with its activating protein TAB1" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of TAK1 kinase - TAB1 chimera fusion protein. This molecule has the UniProt identifier O43318 (M3K7_HUMAN)search. The sample contained 307 residues which is < 90% of the natural sequence. Out of 307 residues 294 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TAK1 kinase - TAB1 chimera fusion protein O43318 (31-412) (M3K7_HUMAN)search Homo sapienssearch < 90% 307 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O43318 (31 - 412) TAK1 kinase - TAB1 chimera fusion protein Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (O43318) transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein kinase activitysearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch