2eua Summary


Structure and Mechanism of MenF, the Menaquinone-Specific Isochorismate Synthase from Escherichia Coli

The structure was published by Kolappan, S., Zwahlen, J., Zhou, R., Truglio, J.J., Tonge, P.J., and Kisker, C., in 2007 in a paper entitled "Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Menaquinone-specific isochorismate synthase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Menaquinone-specific isochorismate synthase P38051 (1-431) (MENF_ECOLI)search Escherichia coli K-12search 100% 431 99%
B Menaquinone-specific isochorismate synthase P38051 (1-431) (MENF_ECOLI)search Escherichia coli K-12search 100% 431 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P38051 (1 - 431) Menaquinone-specific isochorismate synthase Escherichia coli

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B (P38051) ADC synthasesearch PF00425: chorismate binding enzymesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P38051) biosynthetic processsearch menaquinone biosynthetic processsearch isochorismate synthase activitysearch magnesium ion bindingsearch isomerase activitysearch

Chain InterPro annotation
A, B Isochorismate synthasesearch ADC synthasesearch Chorismate-utilising enzyme, C-terminalsearch