2eu3 Summary


Human Carbonic anhydrase II in complex with novel inhibitors

The structure was published by Fisher, S.Z., Govindasamy, L., Boyle, N., et al., Silverman, D.N., Blackburn, G.M., and McKenna, R., in 2006 in a paper entitled "X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) positive regulation of dipeptide transmembrane transportsearch response to steroid hormonesearch bicarbonate transportsearch regulation of intracellular pHsearch odontogenesis of dentin-containing toothsearch response to zinc ionsearch regulation of anion transportsearch small molecule metabolic processsearch response to estrogensearch positive regulation of bone resorptionsearch carbon dioxide transportsearch angiotensin-activated signaling pathwaysearch secretionsearch positive regulation of osteoclast differentiationsearch positive regulation of cellular pH reductionsearch response to organic substancesearch kidney developmentsearch morphogenesis of an epitheliumsearch response to pHsearch carbonate dehydratase activitysearch lyase activitysearch metal ion bindingsearch zinc ion bindingsearch protein bindingsearch cytosolsearch cytoplasmsearch axonsearch plasma membranesearch extracellular spacesearch extracellular vesicular exosomesearch apical part of cellsearch membranesearch basolateral plasma membranesearch microvillussearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch