2eu2 Summary


Human Carbonic Anhydrase II in complex with novel inhibitors

The structure was published by Fisher, S.Z., Govindasamy, L., Boyle, N., et al., Silverman, D.N., Blackburn, G.M., and McKenna, R., in 2006 in a paper entitled "X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.15 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P00918) cytoplasmsearch cytosolsearch extracellular vesicular exosomesearch extracellular spacesearch plasma membranesearch myelin sheathsearch apical part of cellsearch axonsearch membranesearch basolateral plasma membranesearch microvillussearch metal ion bindingsearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch lyase activitysearch regulation of intracellular pHsearch bicarbonate transportsearch response to estrogensearch regulation of chloride transportsearch morphogenesis of an epitheliumsearch response to zinc ionsearch angiotensin-activated signaling pathwaysearch one-carbon metabolic processsearch positive regulation of dipeptide transmembrane transportsearch response to organic substancesearch positive regulation of osteoclast differentiationsearch regulation of anion transportsearch response to pHsearch positive regulation of cellular pH reductionsearch response to steroid hormonesearch positive regulation of synaptic transmission, GABAergicsearch odontogenesis of dentin-containing toothsearch kidney developmentsearch positive regulation of bone resorptionsearch secretionsearch small molecule metabolic processsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch