2etr Summary


Crystal Structure of ROCK I bound to Y-27632

The structure was published by Jacobs, M., Hayakawa, K., Swenson, L., et al., Fleming, M., Taslimi, P., and Doran, J., in 2006 in a paper entitled "The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Rho-associated protein kinase 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Rho-associated protein kinase 1 Q13464 (6-415) (ROCK1_HUMAN)search Homo sapienssearch < 90% 415 96%
B Rho-associated protein kinase 1 Q13464 (6-415) (ROCK1_HUMAN)search Homo sapienssearch < 90% 415 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q13464 (6 - 415) Rho-associated protein kinase 1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Protein kinase C terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q13464) ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Protein kinase, C-terminalsearch