2etl Summary

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Crystal Structure of Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1)

The structure was published by Das, C., Hoang, Q.Q., Kreinbring, C.A., et al., Lansbury, P.T., Ringe, D., and Petsko, G.A., in 2006 in a paper entitled "Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Ubiquitin carboxyl-terminal hydrolase isozyme L1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ubiquitin carboxyl-terminal hydrolase isozyme L1 P09936 (1-223) (UCHL1_HUMAN)search Homo sapienssearch 100% 228 97%
B Ubiquitin carboxyl-terminal hydrolase isozyme L1 P09936 (1-223) (UCHL1_HUMAN)search Homo sapienssearch 100% 228 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P09936 (1 - 223) Ubiquitin carboxyl-terminal hydrolase isozyme L1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P09936) Ubiquitin carboxyl-terminal hydrolase UCH-Lsearch Ubiquitin C-terminal Hydrolase Uch-l3search PF01088: Ubiquitin carboxyl-terminal hydrolase, family 1search

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P09936) intracellularsearch cytoplasmsearch cytosolsearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch nucleussearch membranesearch neuronal cell bodysearch nucleolussearch plasma membranesearch extracellular vesicular exosomesearch axonsearch proteolysissearch ubiquitin-dependent protein catabolic processsearch axonogenesissearch cell proliferationsearch response to ischemiasearch muscle fiber developmentsearch protein deubiquitinationsearch axon target recognitionsearch neuromuscular processsearch eating behaviorsearch adult walking behaviorsearch cell deathsearch axon transport of mitochondrionsearch sensory perception of painsearch negative regulation of MAP kinase activitysearch alpha-2A adrenergic receptor bindingsearch cysteine-type endopeptidase activitysearch peptidase activitysearch ubiquitin thiolesterase activitysearch ligase activitysearch hydrolase activitysearch protein bindingsearch ubiquitin bindingsearch omega peptidase activitysearch ubiquitin-specific protease activitysearch cysteine-type peptidase activitysearch

Chain InterPro annotation
A, B Peptidase C12, ubiquitin carboxyl-terminal hydrolasesearch