› 2erw

X-ray diffraction
1.4Å resolution

Crystal Structure of Infestin 4, a factor XIIa inhibitor

Released:
DOI: 10.2210/pdb2erw/pdb
PDB entry 2erw coloured by chain, front view.
PDB entry 2erw coloured by chain, side view.
PDB entry 2erw coloured by chain, top view.
Source organism: Triatoma infestans
Primary publication:
The Kazal-type inhibitors infestins 1 and 4 differ in specificity but are similar in three-dimensional structure.
Campos IT, Souza TA, Torquato RJ, De Marco R, Tanaka-Azevedo AM, Tanaka AS, Barbosa JA
Acta Crystallogr D Biol Crystallogr 68 695-702 (2012)
PMID: 22683792

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188261 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kazal-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 56 amino acids
Theoretical weight: 6.2 KDa
Source organism: Triatoma infestans
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q95P16 (Residues: 167-222; Coverage: 25%)
Sequence domains: Kazal-type serine protease inhibitor domain
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P212121
Unit cell:
a: 25.765Å b: 45.377Å c: 56.771Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.18 0.19
Expression system: Komagataella pastoris

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Citations

2 review citations

Recent advances on plasmin inhibitors for the treatment of fibrinolysis-related disorders.
Al-Horani et al. (2014)
1 more

10 mentions without citation

Fast and anisotropic flexibility-rigidity index for protein flexibility and fluctuation analysis.
Opron et al. (2014)
9 more