2erj Summary

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Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2

The structure was published by Stauber, D.J., Debler, E.W., Horton, P.A., Smith, K.A., and Wilson, I.A., in 2006 in a paper entitled "Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This entry contains 20 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Interleukin-2 receptor alpha chain P01589 (22-233) (IL2RA_HUMAN)search Homo sapienssearch < 90% 225 58%
E Interleukin-2 receptor alpha chain P01589 (22-233) (IL2RA_HUMAN)search Homo sapienssearch < 90% 225 58%
B Interleukin-2 receptor beta chain P14784 (27-232) (IL2RB_HUMAN)search Homo sapienssearch < 90% 219 93%
F Interleukin-2 receptor beta chain P14784 (27-232) (IL2RB_HUMAN)search Homo sapienssearch < 90% 219 93%
C Cytokine receptor common gamma chain P31785 (23-255) (IL2RG_HUMAN)search Homo sapienssearch < 90% 247 78%
G Cytokine receptor common gamma chain P31785 (23-255) (IL2RG_HUMAN)search Homo sapienssearch < 90% 247 78%
D Interleukin-2 P60568 (21-153) (IL2_HUMAN)search Homo sapienssearch 99% 133 98%
H Interleukin-2 P60568 (21-153) (IL2_HUMAN)search Homo sapienssearch 99% 133 98%


This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
P01589 (22 - 233) Interleukin-2 receptor alpha chain Homo sapiens
P14784 (27 - 232) Interleukin-2 receptor beta chain Homo sapiens
P31785 (23 - 255) Cytokine receptor common gamma chain Homo sapiens
P60568 (21 - 153) Interleukin-2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, E Complement control module/SCR domainsearch Sushi domain (SCR repeat)search
B, F Fibronectin type IIIsearch
C, G Fibronectin type IIIsearch Fibronectin type III domainsearch, Interleukin-6 receptor alpha chain, bindingsearch
D, H (P60568) Short-chain cytokinessearch Growth Hormone; Chain: A;search PF00715: Interleukin 2search

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
B, F (P14784) cytokine receptor activitysearch membranesearch
C, G (P31785) cytokine receptor activitysearch membranesearch
D, H (P60568) interleukin-2 receptor bindingsearch growth factor activitysearch cytokine activitysearch glycosphingolipid bindingsearch carbohydrate bindingsearch kinase activator activitysearch kappa-type opioid receptor bindingsearch extracellular regionsearch extracellular spacesearch positive regulation of inflammatory responsesearch immune responsesearch positive regulation of immunoglobulin secretionsearch positive regulation of tyrosine phosphorylation of Stat5 proteinsearch cell adhesionsearch G-protein coupled receptor signaling pathwaysearch negative regulation of lymphocyte proliferationsearch positive regulation of interleukin-17 productionsearch protein kinase C-activating G-protein coupled receptor signaling pathwaysearch positive regulation of regulatory T cell differentiationsearch positive regulation of isotype switching to IgG isotypessearch positive regulation of activated T cell proliferationsearch elevation of cytosolic calcium ion concentrationsearch positive regulation of T cell proliferationsearch negative regulation of B cell apoptotic processsearch positive regulation of T cell differentiationsearch positive regulation of B cell proliferationsearch positive regulation of tissue remodelingsearch T cell differentiationsearch negative regulation of inflammatory responsesearch positive regulation of cell proliferationsearch negative regulation of protein phosphorylationsearch negative regulation of apoptotic processsearch positive regulation of dendritic spine developmentsearch positive regulation of interferon-gamma productionsearch natural killer cell activationsearch regulation of T cell homeostatic proliferationsearch negative regulation of heart contractionsearch positive regulation of protein phosphorylationsearch positive regulation of transcription from RNA polymerase II promotersearch cell-cell signalingsearch positive regulation of cell growthsearch

Chain InterPro annotation
A, E Sushi/SCR/CCPsearch Interleukin-2 receptor alphasearch
B, F Short hematopoietin receptor, family 1, conserved sitesearch Fibronectin, type IIIsearch Immunoglobulin-like foldsearch
C, G Short hematopoietin receptor, family 1, conserved sitesearch Fibronectin, type IIIsearch Immunoglobulin-like foldsearch Interleukin-6 receptor alpha, bindingsearch
D, H Interleukin-2search Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch