2ecd Summary


Solution structure of the human ABL2 SH2 domain

A publication describing this structure is not available. The depositing authors are Kasai, T.search; Koshiba, S.search; Inoue, M.search; Kigawa, T.search; Yokoyama, S.search; RIKEN Structural Genomics/Proteomics Initiative (RSGI)search

The structure was determined using NMR spectroscopy and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Tyrosine-protein kinase ABL2. This molecule has the UniProt identifier P42684 (ABL2_HUMAN)search. The sample contained 119 residues which is < 90% of the natural sequence. Out of 119 residues 119 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase ABL2 P42684 (163-268) (ABL2_HUMAN)search Homo sapienssearch < 90% 119 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P42684 (163 - 268) Tyrosine-protein kinase ABL2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A SHC Adaptor Proteinsearch SH2 domainsearch

Chain ID Cellular component (GO) Molecular function (GO)
A (P42684) phosphatidylinositol 3-kinase complexsearch phosphatidylinositol 3-kinase regulator activitysearch

Chain InterPro annotation
A SH2 domainsearch PI3 kinase, P85 regulatory subunitsearch