2ec6 Summary


Placopecten Striated Muscle Myosin II

The structure was published by Yang, Y., Gourinath, S., Kovacs, M., et al., Szent-Gyorgyi, A.G., Brown, J.H., and Cohen, C., in 2007 in a paper entitled "Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.25 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Myosin heavy chain, Myosin regulatory light chain, and Myosin essential light chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Myosin heavy chain Q26079 (1-838) (Q26079_PLAMG)search Placopecten magellanicussearch < 90% 838 95%
B Myosin regulatory light chain Q26069 (23-155) (Q26069_PLAMG)search Placopecten magellanicussearch 99% 133 94%
C Myosin essential light chain Q26066 (2-157) (Q26066_PLAMG)search Placopecten magellanicussearch 99% 156 99%

This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
Q26079 (1 - 838) Myosin heavy chain Placopecten magellanicus
Q26069 (23 - 155) Myosin regulatory light chain Placopecten magellanicus
Q26066 (2 - 157) Myosin essential light chain Placopecten magellanicus

Chain Structural classification (CATH) Sequence family (Pfam)
A Myosin head (motor domain)search, Myosin N-terminal SH3-like domainsearch
B (Q26069) EF-handsearch PF13499: EF-hand domain pairsearch
C (Q26066) EF-handsearch PF13499: EF-hand domain pairsearch

Chain ID Molecular function (GO) Cellular component (GO)
A (Q26079) ATP bindingsearch motor activitysearch myosin complexsearch
B (Q26069) calcium ion bindingsearch
C (Q26066) calcium ion bindingsearch metal ion bindingsearch

Chain InterPro annotation
A IQ motif, EF-hand binding sitesearch Myosin head, motor domainsearch Myosin, N-terminal, SH3-likesearch Myosin-like IQ motif-containing domainsearch P-loop containing nucleoside triphosphate hydrolasesearch
B EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
C EF-hand domainsearch EF-hand domain pairsearch