2e7a Summary

pdbe.org/2e7a
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TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity

The structure was published by Shibata, H., Yoshioka, Y., Ohkawa, A., et al., Tsunoda, S., Kamada, H., and Tsutsumi, Y., in 2008 in a paper entitled "Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Tumor necrosis factor.

The molecule most likely forms homotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tumor necrosis factor P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 95%
B Tumor necrosis factor P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 95%
C Tumor necrosis factor P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01375 (77 - 233) Tumor necrosis factor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C Jelly Rollssearch TNF(Tumour Necrosis Factor) familysearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B, C (P01375) membranesearch immune responsesearch tumor necrosis factor receptor bindingsearch

Chain InterPro annotation
A, B, C Tumour necrosis factor alphasearch Tumour necrosis factor domainsearch Tumour necrosis factorsearch Tumour necrosis factor-like domainsearch Tumour necrosis factor, conserved sitesearch