2e43 Summary

pdbe.org/2e43
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Crystal structure of C/EBPbeta Bzip homodimer K269A mutant bound to A High Affinity DNA fragment

A publication describing this structure is not available. The depositing authors are Tahirov, T.H.search; Inoue-Bungo, T.search; Sato, K.search; Shiina, M.search; Hamada, K.search; Ogata, K.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely DNA (5'-D(P*DTP*DAP*DGP*DGP*DAP*DTP*DTP*DGP*DCP*DGP*DCP*DAP*DAP*DTP*DAP*DT)-3'), DNA (5'-D(P*DAP*DAP*DTP*DAP*DTP*DTP*DGP*DCP*DGP*DCP*DAP*DAP*DTP*DCP*DCP*DT)-3'), and CCAAT/enhancer-binding protein beta.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CCAAT/enhancer-binding protein beta P17676 (259-336) (CEBPB_HUMAN)search Homo sapienssearch < 90% 78 82%
B CCAAT/enhancer-binding protein beta P17676 (259-336) (CEBPB_HUMAN)search Homo sapienssearch < 90% 78 82%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P17676 (259 - 336) CCAAT/enhancer-binding protein beta Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Leucine zipper domainsearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch Basic region leucine zippersearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P17676) sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A, B Basic-leucine zipper domainsearch