2e0t Summary


Crystal structure of catalytic domain of dual specificity phosphatase 26, MS0830 from Homo sapiens

The structure was published by Won, E.Y., Xie, Y., Takemoto, C., et al., Yokoyama, S., Kim, S.J., and Chi, S.W., in 2013 in a paper entitled "High-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.67 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Dual specificity phosphatase 26. This molecule has the UniProt identifier Q9BV47 (DUS26_HUMAN)search. The sample contained 151 residues which is < 90% of the natural sequence. Out of 151 residues 150 were observed and are deposited in the PDB.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Dual specificity phosphatase 26 Q9BV47 (61-211) (DUS26_HUMAN)search Homo sapienssearch < 90% 151 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9BV47 (61 - 211) Dual specificity phosphatase 26 Homo sapiens

Chain Sequence family (Pfam)
A Dual specificity phosphatase, catalytic domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q9BV47) protein tyrosine/serine/threonine phosphatase activitysearch protein tyrosine phosphatase activitysearch phosphatase activitysearch protein dephosphorylationsearch dephosphorylationsearch

Chain InterPro annotation
A Dual specificity phosphatase, catalytic domainsearch Protein-tyrosine/Dual specificity phosphatasesearch Protein-tyrosine phosphatase, active sitesearch Atypical dual specificity phosphatase, subfamily Asearch Atypical dual specificity phosphatasesearch Dual specificity phosphatase, subgroup, catalytic domainsearch Dual specificity phosphatasesearch Protein-tyrosine phosphatase-likesearch