2dyl Summary


Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D)

A publication describing this structure is not available. The depositing authors are Kukimoto-Niino, M.search; Takagi, T.search; Kaminishi, T.search; Uchikubo-Kamo, T.search; Terada, T.search; Matsuzaki, O.search; Shirouzu, M.search; Yokoyama, S.search; RIKEN Structural Genomics/Proteomics Initiative (RSGI)search

This crystal structure was determined using X-ray diffraction at a resolution of 2.45 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Dual specificity mitogen-activated protein kinase kinase 7. This molecule has the UniProt identifier O14733 (MP2K7_HUMAN)search. The sample contained 318 residues which is < 90% of the natural sequence. Out of 318 residues 272 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Dual specificity mitogen-activated protein kinase kinase 7 O14733 (101-405) (MP2K7_HUMAN)search Homo sapienssearch < 90% 318 85%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14733 (101 - 405) Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (O14733) protein phosphorylationsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein serine/threonine kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch