› 2dvw

X-ray diffraction
2.3Å resolution

Structure of the Oncoprotein Gankyrin in Complex with S6 ATPase of the 26S Proteasome

Released:
DOI: 10.2210/pdb2dvw/pdb
PDB entry 2dvw coloured by chain, front view.
PDB entry 2dvw coloured by chain, side view.
PDB entry 2dvw coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome.
Nakamura Y, Nakano K, Umehara T, Kimura M, Hayashizaki Y, Tanaka A, Horikoshi M, Padmanabhan B, Yokoyama S
Structure 15 179-89 (2007)
PMID: 17292836

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155123 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
26S proteasome non-ATPase regulatory subunit 10 Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 25.09 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Z2X2 (Residues: 1-231; Coverage: 100%)
Gene name: Psmd10
Sequence domains: Ankyrin repeats (3 copies)
Structure domains: Ankyrin repeat-containing domain
26S proteasome regulatory subunit 6B Chain: B
Molecule details ›
Chain: B
Length: 83 amino acids
Theoretical weight: 9.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43686 (Residues: 337-418; Coverage: 20%)
Gene names: MIP224, PSMC4, TBP7
Sequence domains: AAA+ lid domain
Structure domains: Helicase, Ruva Protein; domain 3

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B1
Spacegroup: P212121
Unit cell:
a: 45.398Å b: 67.886Å c: 107.767Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.169 0.238
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Recognition and processing of ubiquitin-protein conjugates by the proteasome.
Finley D. (2009)
9 more

6 mentions without citation

A primer on ankyrin repeat function in TRP channels and beyond.
Gaudet R. (2008)
5 more