› 2dru

X-ray diffraction
2.6Å resolution

Crystal structure and binding properties of the CD2 and CD244 (2B4) binding protein, CD48

Released:
DOI: 10.2210/pdb2dru/pdb
PDB entry 2dru coloured by chain, front view.
PDB entry 2dru coloured by chain, side view.
PDB entry 2dru coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48.
Evans EJ, Castro MA, O'Brien R, Kearney A, Walsh H, Sparks LM, Tucknott MG, Davies EA, Carmo AM, van der Merwe PA, Stuart DI, Jones EY, Ladbury JE, Ikemizu S, Davis SJ
J Biol Chem 281 29309-20 (2006)
PMID: 16803907

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140432 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD48 antigen; T-cell surface antigen CD2 Chain: A
Molecule details ›
Chain: A
Length: 180 amino acids
Theoretical weight: 21.14 KDa
Source organism: Rattus norvegicus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P10252 (Residues: 23-125; Coverage: 47%)
  • Canonical: P08921 (Residues: 121-197; Coverage: 24%)
Gene names: Bcm-1, Cd2, Cd48
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand NAG 3 x NAG
Ligand GOL 5 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID2
Spacegroup: I4122
Unit cell:
a: 96.78Å b: 96.78Å c: 126.61Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.271
Expression system: Cricetulus griseus

Quick links

Citations

6 review citations

Roles of CD48 in regulating immunity and tolerance.
McArdel et al. (2016)
5 more

5 mentions without citation

Function and 3D structure of the N-glycans on glycoproteins.
Nagae et al. (2012)
4 more