› 2dq7

X-ray diffraction
2.8Å resolution

Crystal Structure of Fyn kinase domain complexed with staurosporine

Released:
DOI: 10.2210/pdb2dq7/pdb
PDB entry 2dq7 coloured by chain, front view.
PDB entry 2dq7 coloured by chain, side view.
PDB entry 2dq7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human Fyn kinase domain complexed with staurosporine.
Kinoshita T, Matsubara M, Ishiguro H, Okita K, Tada T
Biochem Biophys Res Commun 346 840-4 (2006)
PMID: 16782058

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fyn Chain: X
Molecule details ›
Chain: X
Length: 283 amino acids
Theoretical weight: 32.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06241 (Residues: 261-537; Coverage: 52%)
Gene name: FYN
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand STU 1 x STU
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P3221
Unit cell:
a: 52.962Å b: 52.962Å c: 210.989Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.255 0.255 0.281
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Protein kinase inhibition of clinically important staurosporine analogues.
Gani et al. (2010)
19 other articles

30 mentions without citation

The Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells.
Gerbec et al. (2015)
29 more