2dq7 Summary


Crystal Structure of Fyn kinase domain complexed with staurosporine

The structure was published by Kinoshita, T., Matsubara, M., Ishiguro, H., Okita, K., and Tada, T., in 2006 in a paper entitled "Structure of human Fyn kinase domain complexed with staurosporine." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Proto-oncogene tyrosine-protein kinase Fyn. This molecule has the UniProt identifier P06241 (FYN_HUMAN)search. The sample contained 283 residues which is < 90% of the natural sequence. Out of 283 residues 263 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
X Proto-oncogene tyrosine-protein kinase Fyn P06241 (261-537) (FYN_HUMAN)search Homo sapienssearch < 90% 283 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06241 (261 - 537) Proto-oncogene tyrosine-protein kinase Fyn Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
X Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
X (P06241) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
X Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch