2dn3 Summary

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1.25A resolution crystal structure of human hemoglobin in the carbonmonoxy form

The structure was published by Park, S.-Y., Yokoyama, T., Shibayama, N., Shiro, Y., and Tame, J.R., in 2006 in a paper entitled "1.25 a resolution crystal structures of human haemoglobin in the oxy, deoxy and carbonmonoxy forms." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.25 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha subunit and Hemoglobin beta subunit.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha subunit Homo sapiens
P68871 (2 - 147) Hemoglobin beta subunit Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P69905) heme bindingsearch protein bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch iron ion bindingsearch haptoglobin-hemoglobin complexsearch cytosolsearch extracellular vesicular exosomesearch extracellular regionsearch blood microparticlesearch hemoglobin complexsearch membranesearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch response to hydrogen peroxidesearch bicarbonate transportsearch transportsearch small molecule metabolic processsearch oxygen transportsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch oxidation-reduction processsearch
B (P68871) protein bindingsearch oxygen bindingsearch hemoglobin bindingsearch oxygen transporter activitysearch metal ion bindingsearch haptoglobin bindingsearch iron ion bindingsearch peroxidase activitysearch heme bindingsearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolsearch blood microparticlesearch endocytic vesicle lumensearch response to hydrogen peroxidesearch transportsearch regulation of blood vessel sizesearch protein heterooligomerizationsearch bicarbonate transportsearch small molecule metabolic processsearch oxidation-reduction processsearch nitric oxide transportsearch platelet aggregationsearch oxygen transportsearch renal absorptionsearch regulation of blood pressuresearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of cell deathsearch blood coagulationsearch hydrogen peroxide catabolic processsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch