2dn2 Summary

pdbe.org/2dn2
spacer

PDB entry 2dn2 (supersedes 2dfq)

1.25A resolution crystal structure of human hemoglobin in the deoxy form

The structure was published by Park, S.-Y., Yokoyama, T., Shibayama, N., Shiro, Y., and Tame, J.R., in 2006 in a paper entitled "1.25 a resolution crystal structures of human haemoglobin in the oxy, deoxy and carbonmonoxy forms." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.25 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha subunit and Hemoglobin beta subunit.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha subunit Homo sapiens
P68871 (2 - 147) Hemoglobin beta subunit Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) iron ion bindingsearch protein bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen transporter activitysearch heme bindingsearch haptoglobin bindingsearch oxygen bindingsearch oxygen transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch receptor-mediated endocytosissearch protein heterooligomerizationsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch transportsearch small molecule metabolic processsearch oxidation-reduction processsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch cytosolsearch blood microparticlesearch extracellular vesicular exosomesearch membranesearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch
B, D (P68871) heme bindingsearch iron ion bindingsearch peroxidase activitysearch protein bindingsearch metal ion bindingsearch hemoglobin bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch oxygen bindingsearch platelet aggregationsearch regulation of blood pressuresearch renal absorptionsearch blood coagulationsearch bicarbonate transportsearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch protein heterooligomerizationsearch oxygen transportsearch hydrogen peroxide catabolic processsearch transportsearch oxidation-reduction processsearch positive regulation of cell deathsearch nitric oxide transportsearch regulation of blood vessel sizesearch receptor-mediated endocytosissearch response to hydrogen peroxidesearch hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch cytosolsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch