2dn2 Summary

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PDB entry 2dn2 (supersedes 2dfq)

1.25A resolution crystal structure of human hemoglobin in the deoxy form

The structure was published by Park, S.-Y., Yokoyama, T., Shibayama, N., Shiro, Y., and Tame, J.R., in 2006 in a paper entitled "1.25 a resolution crystal structures of human haemoglobin in the oxy, deoxy and carbonmonoxy forms." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.25 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha subunit and Hemoglobin beta subunit.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha subunit Homo sapiens
P68871 (2 - 147) Hemoglobin beta subunit Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C (P69905) hemoglobin complexsearch extracellular regionsearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch extracellular vesicular exosomesearch membranesearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch oxygen transportsearch protein heterooligomerizationsearch transportsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch bicarbonate transportsearch oxidation-reduction processsearch small molecule metabolic processsearch response to hydrogen peroxidesearch iron ion bindingsearch oxygen bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch haptoglobin bindingsearch heme bindingsearch
B, D (P68871) hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch cytosolsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch renal absorptionsearch transportsearch platelet aggregationsearch small molecule metabolic processsearch bicarbonate transportsearch positive regulation of nitric oxide biosynthetic processsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch oxygen transportsearch regulation of blood pressuresearch response to hydrogen peroxidesearch blood coagulationsearch nitric oxide transportsearch regulation of blood vessel sizesearch positive regulation of cell deathsearch oxidation-reduction processsearch protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch iron ion bindingsearch oxygen bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch heme bindingsearch peroxidase activitysearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch