2dn1 Summary

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PDB entry 2dn1 (supersedes 2dfo)

1.25A resolution crystal structure of human hemoglobin in the oxy form

The structure was published by Park, S.-Y., Yokoyama, T., Shibayama, N., Shiro, Y., and Tame, J.R., in 2006 in a paper entitled "1.25 a resolution crystal structures of human haemoglobin in the oxy, deoxy and carbonmonoxy forms." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.25 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha subunit and Hemoglobin beta subunit.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 99%
B Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha subunit Homo sapiens
P68871 (2 - 147) Hemoglobin beta subunit Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P69905) peroxidase activitysearch haptoglobin bindingsearch oxygen transporter activitysearch iron ion bindingsearch protein bindingsearch oxygen bindingsearch heme bindingsearch metal ion bindingsearch extracellular regionsearch cytosolsearch hemoglobin complexsearch membranesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch blood microparticlesearch transportsearch receptor-mediated endocytosissearch positive regulation of cell deathsearch oxygen transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch protein heterooligomerizationsearch oxidation-reduction processsearch
B (P68871) peroxidase activitysearch haptoglobin bindingsearch oxygen transporter activitysearch iron ion bindingsearch protein bindingsearch oxygen bindingsearch heme bindingsearch hemoglobin bindingsearch metal ion bindingsearch extracellular regionsearch cytosolsearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch blood microparticlesearch transportsearch receptor-mediated endocytosissearch blood coagulationsearch regulation of blood pressuresearch positive regulation of cell deathsearch oxygen transportsearch bicarbonate transportsearch nitric oxide transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch protein heterooligomerizationsearch oxidation-reduction processsearch renal absorptionsearch platelet aggregationsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch