2dln Summary

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VANCOMYCIN RESISTANCE: STRUCTURE OF D-ALANINE:D-ALANINE LIGASE AT 2.3 ANGSTROMS RESOLUTION

The structure was published by Fan, C., Moews, P.C., Walsh, C.T., and Knox, J.R., in 1994 in a paper entitled "Vancomycin resistance: structure of D-alanine:D-alanine ligase at 2.3 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of D-ALANINE--D-ALANINE LIGASE. This molecule has the UniProt identifier P07862 (DDLB_ECOLI)search. The sample contained 306 residues which is 100% of the natural sequence. Out of 306 residues 306 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A D-ALANINE--D-ALANINE LIGASE P07862 (1-306) (DDLB_ECOLI)search Escherichia coli K-12search 100% 306 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P07862 (1 - 306) D-ALANINE--D-ALANINE LIGASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P07862) D-Alanine ligase N-terminal domainsearch, ATP-binding domain of peptide synthetasessearch Rossmann foldsearch, ATP-grasp fold, B domainsearch, ATP-grasp fold, A domainsearch PF01820: D-ala D-ala ligase N-terminussearch, PF07478: D-ala D-ala ligase C-terminussearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P07862) ATP bindingsearch D-alanine-D-alanine ligase activitysearch metal ion bindingsearch catalytic activitysearch nucleotide bindingsearch magnesium ion bindingsearch manganese ion bindingsearch ligase activitysearch cytoplasmsearch peptidoglycan biosynthetic processsearch cell wall organizationsearch regulation of cell shapesearch

Chain InterPro annotation
A D-alanine--D-alanine ligase/VANA/B/C, conserved sitesearch D-alanine--D-alanine ligasesearch D-alanine--D-alanine ligase, C-terminalsearch D-alanine--D-alanine ligase, N-terminal domainsearch ATP-grasp foldsearch ATP-grasp fold, subdomain 1search ATP-grasp fold, subdomain 2search Pre-ATP-grasp domainsearch