2djf Summary

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Crystal Structure of human dipeptidyl peptidase I (Cathepsin C) in complex with the inhibitor Gly-Phe-CHN2

The structure was published by Molgaard, A., Arnau, J., Lauritzen, C., Larsen, S., Petersen, G., and Pedersen, J., in 2007 in a paper entitled "The crystal structure of human dipeptidyl peptidase I (cathepsin C) in complex with the inhibitor Gly-Phe-CHN2" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Dipeptidyl-peptidase 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 12meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Dipeptidyl-peptidase 1 P53634 (25-143) (CATC_HUMAN)search Homo sapienssearch 100% 119 99%
B Dipeptidyl-peptidase 1 P53634 (231-394) (CATC_HUMAN)search Homo sapienssearch 100% 164 98%
C Dipeptidyl-peptidase 1 P53634 (395-463) (CATC_HUMAN)search Homo sapienssearch 100% 69 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P53634 (25 - 143) Dipeptidyl-peptidase 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P53634) Dipeptidyl peptidase I (cathepsin C), exclusion domainsearch Lipocalinsearch PF08773: Cathepsin C exclusion domainsearch
B (P53634) Cysteine proteinasessearch PF00112: Papain family cysteine proteasesearch
C (P53634) Cysteine proteinases. Chain Csearch PF00112: Papain family cysteine proteasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P53634) cysteine-type peptidase activitysearch
B (P53634) cysteine-type peptidase activitysearch proteolysissearch
C (P53634) cysteine-type peptidase activitysearch proteolysissearch

Chain InterPro annotation
A Peptidase C1Asearch Cathepsin C exclusionsearch
B Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch
C Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch