2d60 Summary

pdbe.org/2d60
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Crystal structure of deoxy human hemoglobin complexed with two L35 molecules

The structure was published by Yokoyama, T., Neya, S., Tsuneshige, A., Yonetani, T., Park, S.Y., and Tame, J.R., in 2006 in a paper entitled "R-state haemoglobin with low oxygen affinity: crystal structures of deoxy human and carbonmonoxy horse haemoglobin bound to the effector molecule L35" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha subunit and Hemoglobin beta subunit.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 99%
D Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha subunit Homo sapiens
P68871 (2 - 147) Hemoglobin beta subunit Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) heme bindingsearch iron ion bindingsearch oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen transportsearch small molecule metabolic processsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch bicarbonate transportsearch transportsearch hydrogen peroxide catabolic processsearch receptor-mediated endocytosissearch oxidation-reduction processsearch protein heterooligomerizationsearch extracellular exosomesearch extracellular regionsearch membranesearch cytosolsearch blood microparticlesearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch
B, D (P68871) heme bindingsearch iron ion bindingsearch oxygen bindingsearch metal ion bindingsearch protein bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch peroxidase activitysearch oxygen transporter activitysearch oxygen transportsearch receptor-mediated endocytosissearch blood coagulationsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch positive regulation of nitric oxide biosynthetic processsearch renal absorptionsearch transportsearch positive regulation of cell deathsearch regulation of blood pressuresearch platelet aggregationsearch small molecule metabolic processsearch oxidation-reduction processsearch response to hydrogen peroxidesearch nitric oxide transportsearch protein heterooligomerizationsearch regulation of blood vessel sizesearch extracellular exosomesearch blood microparticlesearch hemoglobin complexsearch extracellular regionsearch cytosolsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch