2d5z Summary

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Crystal structure of T-state human hemoglobin complexed with three L35 molecules

The structure was published by Yokoyama, T., Neya, S., Tsuneshige, A., Yonetani, T., Park, S.Y., and Tame, J.R., in 2006 in a paper entitled "R-state haemoglobin with low oxygen affinity: crystal structures of deoxy human and carbonmonoxy horse haemoglobin bound to the effector molecule L35" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.45 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha subunit and Hemoglobin beta subunit.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 99%
D Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha subunit Homo sapiens
P68871 (2 - 147) Hemoglobin beta subunit Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) heme bindingsearch iron ion bindingsearch oxygen bindingsearch protein bindingsearch metal ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch peroxidase activitysearch transportsearch receptor-mediated endocytosissearch bicarbonate transportsearch oxygen transportsearch small molecule metabolic processsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch positive regulation of cell deathsearch extracellular regionsearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch cytosolsearch endocytic vesicle lumensearch membranesearch hemoglobin complexsearch
B, D (P68871) iron ion bindingsearch heme bindingsearch oxygen bindingsearch protein bindingsearch hemoglobin bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch oxidation-reduction processsearch renal absorptionsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch oxygen transportsearch positive regulation of cell deathsearch regulation of blood vessel sizesearch bicarbonate transportsearch receptor-mediated endocytosissearch blood coagulationsearch positive regulation of nitric oxide biosynthetic processsearch platelet aggregationsearch transportsearch regulation of blood pressuresearch nitric oxide transportsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch cytosolsearch extracellular vesicular exosomesearch blood microparticlesearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch