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PDBe Entry: 2cw0 view

Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution
Summary
Header TRANSFERASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 3.3 Å, R-factor: 28.2%, Free R-factor: 32.0%, Spacegroup: P 32
Released 20/09/2005, deposition: 15/06/2005, last revision: 24/02/2009
Authors Tuske, S.search; Sarafianos, S.G.search; Wang, X.search; Hudson, B.search; Sineva, E.search; Mukhopadhyay, J.search; Birktoft, J.J.search; Leroy, O.search; Ismail, S.search; Clark Jr., A.D.search; Dharia, C.search; Napoli, A.search; Laptenko, O.search; Lee, J.search; Borukhov, S.search; Ebright, R.H.search; Arnold, E.search
Primary citation Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
CELL(CAMBRIDGE,MASS.)search vol:122, pag:541-552 (2005) [PubMed ID 16122422 ]search
Keywords RNA polymerase holoenzymesearch, transcriptionsearch, bent-bridge helixsearch, TRANSFERASEsearch
EC 2.7.7.6 ExPASy BRENDA search (A B C D E K L M N O)
Organism Thermus thermophilus 274search(A B K L E O),Thermus thermophilus HB8 300852search(C M D N),Thermus thermophilus HB27 262724search(F P)
UniProt DNA-directed RNA polymerase subunit alpha (EC 2.7.7.6) (RNAP subunit alpha) (Transcriptase subunit alpha) (RNA polymerase subunit alpha) Q9Z9H6search (A B K L)
DNA-directed RNA polymerase subunit beta (EC 2.7.7.6) (RNAP subunit beta) (Transcriptase subunit beta) (RNA polymerase subunit beta) Q8RQE9search (C M)
DNA-directed RNA polymerase subunit beta' (EC 2.7.7.6) (RNAP subunit beta') (Transcriptase subunit beta') (RNA polymerase subunit beta') Q8RQE8search (D N)
DNA-directed RNA polymerase subunit omega (EC 2.7.7.6) (RNAP omega subunit) (Transcriptase subunit omega) (RNA polymerase omega subunit) Q8RQE7search (E O)
RNA polymerase sigma factor rpoD Q72L95search (F P)
Polymers
Id Name Type UniProt Residues Observed
A, B, K, L DNA-directed RNA polymerase alpha chain Protein Q9Z9H6 (RPOA_THETH)search
315 72%
C, M DNA-directed RNA polymerase beta chain Protein Q8RQE9 (RPOB_THET8)search
1119 100%
D, N DNA-directed RNA polymerase beta' chain Protein Q8RQE8 (RPOC_THET8)search
1524 91%
E, O RNA polymerase omega chain Protein Q8RQE7 (RPOZ_THET8)search
99 95%
F, P RNA polymerase sigma factor rpoD Protein Q72L95 (Q72L95_THET2)search
423 81%
Heterogens
Id Name Ligands
D, N ZINC ION ZN search
D, N MAGNESIUM ION MG search
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