› 2cmo

X-ray diffraction
2.65Å resolution

The structure of a mixed glur2 ligand-binding core dimer in complex with (s)-glutamate and the antagonist (s)-ns1209

Released:
DOI: 10.2210/pdb2cmo/pdb
PDB entry 2cmo coloured by chain, front view.
PDB entry 2cmo coloured by chain, side view.
PDB entry 2cmo coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209.
Kasper C, Pickering DS, Mirza O, Olsen L, Kristensen AS, Greenwood JR, Liljefors T, Schousboe A, Wätjen F, Gajhede M, Sigurskjold BW, Kastrup JS
J Mol Biol 357 1184-201 (2006)
PMID: 16483599

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 263 amino acids
Theoretical weight: 29.22 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19491 (Residues: 413-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand SO4 4 x SO4
Ligand M1L 1 x M1L
Ligand GLU 1 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 62.554Å b: 92.953Å c: 96.454Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.215 0.281
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
10 more

6 mentions without citation

Size matters in activation/inhibition of ligand-gated ion channels.
Du et al. (2012)
5 more