2clx Summary



The structure was published by Krystof, V., Cankar, P., Frysova, I., et al., Latr, A., Fischer, P.M., and Strnad, M., in 2006 in a paper entitled "4-Arylazo-3,5-Diamino-1H-Pyrazole Cdk Inhibitors: Sar Study, Crystal Structure in Complex with Cdk2, Selectivity, and Cellular Effects" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 292 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch nucleotide bindingsearch cyclin bindingsearch kinase activitysearch transferase activitysearch metal ion bindingsearch histone kinase activitysearch protein phosphorylationsearch positive regulation of cell proliferationsearch G1/S transition of mitotic cell cyclesearch DNA replicationsearch Ras protein signal transductionsearch positive regulation of transcription, DNA-templatedsearch regulation of gene silencingsearch mitotic G1 DNA damage checkpointsearch meiotic nuclear divisionsearch DNA repairsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cell divisionsearch phosphorylationsearch potassium ion transportsearch G2/M transition of mitotic cell cyclesearch mitotic cell cyclesearch histone phosphorylationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch positive regulation of DNA-dependent DNA replication initiationsearch cell cyclesearch centrosome duplicationsearch cellular response to DNA damage stimulussearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch blood coagulationsearch cellular response to nitric oxidesearch mitotic nuclear divisionsearch nucleoplasmsearch transcription factor complexsearch centrosomesearch Cajal bodysearch condensed chromosomesearch endosomesearch cytoskeletonsearch cytoplasmsearch cyclin-dependent protein kinase holoenzyme complexsearch microtubule organizing centersearch nucleussearch cytosolsearch chromosome, telomeric regionsearch Y chromosomesearch X chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch