2cio Summary

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THE HIGH RESOLUTION X-RAY STRUCTURE OF PAPAIN COMPLEXED WITH FRAGMENTS OF THE TRYPANOSOMA BRUCEI CYSTEINE PROTEASE INHIBITOR ICP.

The structure was published by Alphey, M.S. and Hunter, W.N., in 2006 in a paper entitled "High-Resolution Complex of Papain with Remnants of a Cysteine Protease Inhibitor Derived from Trypanosoma Brucei" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PAPAIN and INHIBITOR OF CYSTEINE PEPTIDASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PAPAIN P00784 (134-345) (PAPA1_CARPA)search Carica papayasearch 98% 212 100%
B INHIBITOR OF CYSTEINE PEPTIDASE Q868H0 (1-121) (Q868H0_9TRYP)search Trypanosoma bruceisearch 100% 121 5%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00784 (134 - 345) PAPAIN Carica papaya
Q868H0 (1 - 121) INHIBITOR OF CYSTEINE PEPTIDASE Trypanosoma brucei

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00784) Cysteine proteinasessearch PF00112: Papain family cysteine proteasesearch
B Chagasin family peptidase inhibitor I42search

Chain ID Molecular function (GO) Biological process (GO)
A (P00784) cysteine-type peptidase activitysearch proteolysissearch

Chain InterPro annotation
A Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch
B Proteinase inhibitor I42, chagasinsearch