2chx Summary

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A PHARMACOLOGICAL MAP OF THE PI3-K FAMILY DEFINES A ROLE FOR P110ALPHA IN SIGNALING: THE STRUCTURE OF COMPLEX OF PHOSPHOINOSITIDE 3-KINASE GAMMA WITH INHIBITOR PIK-90

The structure was published by Knight, Z.A., Gonzalez, B., Feldman, M.E., et al., Weiss, W.A., Williams, R.L., and Shokat, K.M., in 2006 in a paper entitled "A Pharmacological Map of the Pi3-K Family Defines a Role for P110Alpha in Signaling" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM P48736 (144-1102) (PK3CG_HUMAN)search Homo sapienssearch < 90% 966 87%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P48736 (144 - 1102) PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1search, C2- domain Calcium/lipid binding domainsearch, Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch, Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4search, Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 5search Phosphatidylinositol 3- and 4-kinasesearch, Phosphoinositide 3-kinase family, accessory domain (PIK domain)search, Phosphoinositide 3-kinase C2search, PI3-kinase family, ras-binding domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (P48736) phosphatidylinositol-mediated signalingsearch phosphatidylinositol phosphorylationsearch phosphotransferase activity, alcohol group as acceptorsearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A C2 domainsearch Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domainsearch Phosphatidylinositol 3-/4-kinase, catalytic domainsearch Phosphoinositide 3-kinase, accessory (PIK) domainsearch Phosphatidylinositol 3-kinase, C2 domainsearch Protein kinase-like domainsearch Phosphatidylinositol Kinasesearch Armadillo-type foldsearch Phosphatidylinositol 3/4-kinase, conserved sitesearch Ubiquitin-related domainsearch