PDB entry 2cfq

SUGAR FREE LACTOSE PERMEASE AT NEUTRAL PH

Download PDB file View in 3D Similar structures Quaternary structure

The structure was published by Mirza, O., Guan, L., Verner, G., Iwata, S., and Kaback, H.R., in 2006 in a paper entitled "Structural Evidence for Induced Fit and a Mechanism for Sugar/H(+) Symport in Lacy." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.95 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of LACTOSE PERMEASE. This molecule has the UniProt identifier P02920 (LACY_ECOLI). The sample contained 417 residues which is 100% of the natural sequence. Out of 417 residues 417 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain	Name	UniProt	Name of source organism	% of UniProt sequence present in the sample	Residues in the sample molecules	% of residues observed
A	LACTOSE PERMEASE	P02920 (1-417) (LACY_ECOLI)	Escherichia coli K-12	100%	417	100%

This entry contains 1 unique UniProt protein:

UniProt accession	Name	Organism	PDB
P02920 (1 - 417)	LACTOSE PERMEASE	Escherichia coli	Related PDB sequences UniProt coverage

Chain	Structural classification (SCOP)	Structural classification (CATH)	Sequence family (Pfam)
A (P02920)	LacY-like proton/sugar symporter	MFS general substrate transporter like domains	LacY proton/sugar symporter

Chain ID	Molecular function (GO)	Cellular component (GO)	Biological process (GO)
A (P02920)	Sugar:hydrogen symporter activity, Symporter activity, Lactose:hydrogen symporter activity, Lactose binding	Plasma membrane, Integral to plasma membrane, Membrane, Integral to membrane	Transport, Carbohydrate transport, Lactose transport

Chain	InterPro annotation
A	Proton/sugar symporter, LacY, bacterial-type, Major facilitator superfamily domain, general substrate transporter, Proton/sugar symporter, LacY, conserved site, Major facilitator superfamily domain, Proton/sugar symporter, LacY