2cci Summary

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CRYSTAL STRUCTURE OF PHOSPHO-CDK2 CYCLIN A IN COMPLEX WITH A PEPTIDE CONTAINING BOTH THE SUBSTRATE AND RECRUITMENT SITES OF CDC6

The structure was published by Cheng, K.Y., Noble, M.E.M., Skamnaki, V., et al., Cole, P.A., Siligardi, G., and Johnson, L.N., in 2006 in a paper entitled "The Role of the Phospho-Cdk2/Cyclin a Recruitment Site in Substrate Recognition" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, and CELL DIVISION CONTROL PROTEIN 6 HOMOLOG.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 99%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 99%
B CYCLIN A2 P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 100%
D CYCLIN A2 P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 100%
F CELL DIVISION CONTROL PROTEIN 6 HOMOLOG Q99741 (71-100) (CDC6_HUMAN)search Homo sapienssearch < 90% 30 63%
I CELL DIVISION CONTROL PROTEIN 6 HOMOLOG Q99741 (73-100) (CDC6_HUMAN)search Homo sapienssearch < 90% 30 63%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (175 - 432) CYCLIN A2 Homo sapiens
Q99741 (71 - 100) CELL DIVISION CONTROL PROTEIN 6 HOMOLOG HOMO SAPIENS

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch
F, I

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, C (P24941) protein phosphorylationsearch DNA replicationsearch positive regulation of DNA-dependent DNA replication initiationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch meiotic cell cyclesearch cellular response to DNA damage stimulussearch cell cyclesearch G2/M transition of mitotic cell cyclesearch positive regulation of cell proliferationsearch cell divisionsearch cellular response to nitric oxidesearch blood coagulationsearch potassium ion transportsearch positive regulation of transcription, DNA-templatedsearch G1/S transition of mitotic cell cyclesearch centrosome duplicationsearch histone phosphorylationsearch mitotic G1 DNA damage checkpointsearch meiotic nuclear divisionsearch regulation of gene silencingsearch mitotic nuclear divisionsearch mitotic cell cyclesearch phosphorylationsearch Ras protein signal transductionsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch DNA repairsearch nucleoplasmsearch endosomesearch X chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch nucleussearch cytoplasmsearch cytoskeletonsearch Cajal bodysearch cytosolsearch centrosomesearch microtubule organizing centersearch Y chromosomesearch chromosome, telomeric regionsearch transcription factor complexsearch condensed chromosomesearch protein kinase activitysearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch transferase activitysearch ATP bindingsearch histone kinase activitysearch nucleotide bindingsearch cyclin bindingsearch kinase activitysearch metal ion bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch
B, D (P20248) regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of cell cyclesearch regulation of G2/M transition of mitotic cell cyclesearch nucleussearch protein kinase bindingsearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/F/Osearch Cyclin A, chordatessearch
F, I