2cci Summary

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CRYSTAL STRUCTURE OF PHOSPHO-CDK2 CYCLIN A IN COMPLEX WITH A PEPTIDE CONTAINING BOTH THE SUBSTRATE AND RECRUITMENT SITES OF CDC6

The structure was published by Cheng, K.Y., Noble, M.E.M., Skamnaki, V., et al., Cole, P.A., Siligardi, G., and Johnson, L.N., in 2006 in a paper entitled "The Role of the Phospho-Cdk2/Cyclin a Recruitment Site in Substrate Recognition" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, and CELL DIVISION CONTROL PROTEIN 6 HOMOLOG.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 99%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 99%
B CYCLIN A2 P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 100%
D CYCLIN A2 P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 100%
F CELL DIVISION CONTROL PROTEIN 6 HOMOLOG Q99741 (71-100) (CDC6_HUMAN)search Homo sapienssearch < 90% 30 63%
I CELL DIVISION CONTROL PROTEIN 6 HOMOLOG Q99741 (73-100) (CDC6_HUMAN)search Homo sapienssearch < 90% 30 63%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (175 - 432) CYCLIN A2 Homo sapiens
Q99741 (71 - 100) CELL DIVISION CONTROL PROTEIN 6 HOMOLOG HOMO SAPIENS

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch
F, I

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P24941) protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch cyclin bindingsearch kinase activitysearch transferase activitysearch nucleotide bindingsearch histone kinase activitysearch metal ion bindingsearch protein phosphorylationsearch DNA replicationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch positive regulation of cell proliferationsearch cell divisionsearch phosphorylationsearch DNA repairsearch G2/M transition of mitotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch histone phosphorylationsearch cellular response to nitric oxidesearch meiotic cell cyclesearch blood coagulationsearch meiotic nuclear divisionsearch regulation of gene silencingsearch cellular response to DNA damage stimulussearch mitotic G1 DNA damage checkpointsearch G1/S transition of mitotic cell cyclesearch positive regulation of DNA-dependent DNA replication initiationsearch centrosome duplicationsearch mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch Ras protein signal transductionsearch potassium ion transportsearch mitotic nuclear divisionsearch nucleoplasmsearch condensed chromosomesearch chromosome, telomeric regionsearch cyclin-dependent protein kinase holoenzyme complexsearch cytoskeletonsearch endosomesearch centrosomesearch cytosolsearch Y chromosomesearch nucleussearch cytoplasmsearch transcription factor complexsearch X chromosomesearch Cajal bodysearch
B, D (P20248) protein kinase bindingsearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch
F, I