2cbl Summary



The structure was published by Meng, W., Sawasdikosol, S., Burakoff, S.J., and Eck, M.J., in 1999 in a paper entitled "Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTO-ONCOGENE CBL and ZAP-70.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTO-ONCOGENE CBL P22681 (47-351) (CBL_HUMAN)search Homo sapienssearch < 90% 305 100%
B ZAP-70 P43403 (286-297) (ZAP70_HUMAN)search Homo sapienssearch 98% 12 75%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P22681 (47 - 351) PROTO-ONCOGENE CBL Homo sapiens
P43403 (286 - 297) ZAP-70

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A EF-hand modules in multidomain proteinssearch, N-terminal domain of cbl (N-cbl)search, SH2 domainsearch N-terminal domain of cbl (N-cbl)search, EF-handsearch, SHC Adaptor Proteinsearch CBL proto-oncogene N-terminal domain 1search, CBL proto-oncogene N-terminus, EF hand-like domainsearch, CBL proto-oncogene N-terminus, SH2-like domainsearch
B (P43403)

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P22681) phosphotyrosine bindingsearch ubiquitin-protein transferase activitysearch signal transducer activitysearch calcium ion bindingsearch nucleussearch cell surface receptor signaling pathwaysearch regulation of signalingsearch

Chain InterPro annotation
A SH2 domainsearch Adaptor protein Cbl, N-terminal helicalsearch EF-hand domain pairsearch Adaptor protein Cbl, EF hand-likesearch Adaptor protein Cbl, SH2-likesearch Adaptor protein Cbl, PTB domainsearch Adaptor protein Cblsearch