2cbd Summary

pdbe.org/2cbd
spacer

STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES

The structure was published by Hakansson, K., Carlsson, M., Svensson, L.A., and Liljas, A., in 1992 in a paper entitled "Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.67 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P00918) extracellular spacesearch cytoplasmsearch myelin sheathsearch microvillussearch membranesearch basolateral plasma membranesearch cytosolsearch apical part of cellsearch plasma membranesearch extracellular vesicular exosomesearch axonsearch carbonate dehydratase activitysearch metal ion bindingsearch protein bindingsearch zinc ion bindingsearch lyase activitysearch regulation of chloride transportsearch positive regulation of dipeptide transmembrane transportsearch angiotensin-activated signaling pathwaysearch one-carbon metabolic processsearch positive regulation of cellular pH reductionsearch cellular response to fluid shear stresssearch bicarbonate transportsearch regulation of anion transportsearch morphogenesis of an epitheliumsearch response to estrogensearch regulation of intracellular pHsearch small molecule metabolic processsearch response to organic substancesearch kidney developmentsearch positive regulation of bone resorptionsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of osteoclast differentiationsearch response to steroid hormonesearch odontogenesis of dentin-containing toothsearch response to pHsearch response to zinc ionsearch secretionsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch