› 2c9a

X-ray diffraction
2.7Å resolution

Crystal structure of the MAM-Ig module of receptor protein tyrosine phosphatase mu

Released:
DOI: 10.2210/pdb2c9a/pdb
PDB entry 2c9a coloured by chain, front view.
PDB entry 2c9a coloured by chain, side view.
PDB entry 2c9a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion.
Aricescu AR, Hon WC, Siebold C, Lu W, van der Merwe PA, Jones EY
EMBO J 25 701-12 (2006)
PMID: 16456543

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151294 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Receptor-type tyrosine-protein phosphatase mu Chain: A
Molecule details ›
Chain: A
Length: 259 amino acids
Theoretical weight: 29.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P28827 (Residues: 21-279; Coverage: 18%)
Gene names: PTPRL1, PTPRM
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
2 bound ligands:
Ligand NAG 1 x NAG
Ligand NA 2 x NA
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: I222
Unit cell:
a: 58.856Å b: 97.737Å c: 134.357Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.222 0.275
Expression system: Homo sapiens

Quick links

Citations

17 review citations

Protein-tyrosine phosphatases and cancer.
Ostman et al. (2006)
16 more

7 mentions without citation

Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion.
Aricescu et al. (2006)
6 more