2c80 Summary

pdbe.org/2c80
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Structure of Sh28GST in complex with S-hexyl Glutathione

The structure was published by Baiocco, P., Gourlay, L.J., Angelucci, F., et al., Trottein, F., Brunori, M., and Bellelli, A., in 2006 in a paper entitled "Probing the Mechanism of Gsh Activation in Schistosoma Haematobium Glutathione-S-Transferase by Site-Directed Mutagenesis and X-Ray Crystallography." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of GLUTATHIONE S-TRANSFERASE 28 KDA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLUTATHIONE S-TRANSFERASE 28 KDA P30113 (1-211) (GST28_SCHBO)search Schistosoma bovissearch 100% 211 98%
B GLUTATHIONE S-TRANSFERASE 28 KDA P30113 (1-211) (GST28_SCHBO)search Schistosoma bovissearch 100% 211 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P30113 (1 - 211) GLUTATHIONE S-TRANSFERASE 28 KDA Schistosoma haematobium

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P30113) Glutathione S-transferase (GST), C-terminal domainsearch, Glutathione S-transferase (GST), N-terminal domainsearch Glutaredoxinsearch, Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2search PF00043: Glutathione S-transferase, C-terminal domainsearch, PF02798: Glutathione S-transferase, N-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P30113) transferase activitysearch glutathione transferase activitysearch metabolic processsearch

Chain InterPro annotation
A, B Glutathione S-transferase, N-terminalsearch Glutathione S-transferase, C-terminalsearch Glutathione S-transferase, C-terminal-likesearch Thioredoxin-like foldsearch